I'm fine with superhero play. I just don't want getting there to be so non-intuitive.
Maybe let each character pick a schtick. A nimble character's could be "unhittable," and it lets her have an effective +5 bonus to her Dexterity modifier for the purposes of AC and Reflex saves, but only if she's not wearing armor. (Increasing a point every few levels.) The trick to threatening her is denying her Dex mod, or targeting non-Dex defenses.
But her AC could then be easily calculated: 10 + Dex mod. No Wisdom, no dodge, no enhancement, luck, deflection, insight, natural armor. Just give every PC the same formula 10 + Dex + armor + magic (+ cover in some circumstances).
Likewise, a warrior might have the schtick "strong as a giant," which would give him the ability to wield weapons as if he was a size larger, and grant him a +5 bonus to his Strength modifier for the purpose of damage. His attack bonus would be d20 + some small base attack bonus + Str + magic (+ circumstance for things like flanking).
I don't see how the complexity caused by having so many non-obvious bonuses provides much in the way of benefits.