I just had a thought - I think Theros works petty well as a proof-of-potential for Kara-Tur. A lot of the potential problems of an "Oriental Adventures" (like even just that name) can be avoided by making an "eastern"-inspired setting that is meant to be fantasy, in a similar way that Theros is Greek, but not-on-the-nose Greek.
If you make a Kara-Tur that is respectful of, and inspired by, "eastern" myths and legends, while being it's own fantasy beast, I think you could avoid the potential problematic aspects of it, while making a very interesting fantasy setting, with a feel that is quite different from, say, the Sword Coast.
I can imagine a pretty interesting Monsters Manual section for it, as well as a good place for some subclasses that are still missing from 5e. What do you all think?