Hussar
Legend
That would be my personal version of hell as a player or a DM. Play in one setting? No thank you. The world of fantasy is far, far to large to play in one setting.Thing is, if you get it right the initial world-building process is something you really only have to do once. After that, you can run short campaign after short campaign in that same setting, slowly expanding on it as you go.
Lessee, since 5e released I've played or DM'd:
Dragonlance
Forgotten Realms - Storm King's Thunder, Candlekeep Mysteries, Dungeon of the Mad Mage, Dragonheist, Tyranny of Dragons, Phandallin and Shattered Obelisk
Spelljammer (although that one was 99% homebrew)
The Chaos Scar (a rebuild of the Keep on the Borderlands for 4e that I brought forward to 5e - very sandboxy.

Ravenloft
Currently doing Out of the Abyss which is also Forgotten Realms, although very niche.
So, either played or DM'd 12 different campaigns in the past ten years. Note, a lot of those were concurrent. So, yeah, zero interest in playing one campaign setting for seventeen years.