Quebec separates in many RPG products. I'm thinking of CyberPunk, Twilight 2000 and other near future RPGs.
In Twilight 2000, the separation of Quebec actually has an effect on the Canadian military because the armour divisions out East didn't actually have any... armour... when the separation happened. So the Mechanized Infantry divisions out East use requisitioned pickup trucks and so on.
Free Quebec in RIFTS is a humanocentric and xenophobic patriotic nation that ends up looking like a good guy in the face of the even more humanocentric and xenophobic Coalition based out of Chicago. In RIFTS, they have access to a technology that no one else has (except for a company in Germany that they sold the tech to in exchange for manufacturing capacity) that makes them stand out.
CyberSpace has very little reference to Canada - in 2067 Canada is the first nation to commence extensive Aqualogy development (off the coast of BC). In 2073 Quebec secedes from Canada. In 2075 Quebec rejoins Canada. The US annexes Ontario as a "Protectorate" in 2077. I also believe that there was a reference to the Stanley Cup and to Canadian Tire Money in sidebars in some of the other books in the line, but those are out in another room right now.
In CyberPunk, Canadian crops are wiped out with most of the world's in 2002 (only US crops survive, because the virus was a bioweapon and the US had the cure - you do the math). I don't think that Canada sees any other mention in the core book - but I'm sure there's references to it in other books (especially the 'unofficial' ones published by DP9 and written by a Montrealer).
In Underground, Canada (except for Quebec) is part of the US. They needed more states. 60 States (the classic 50 + the Canadian Provinces + Cuba). The People's Republic of Quebec (with a population of 8.5 million) is primarily Protestant and Scientologist in 2021. (oooooooh kay...) It separated in 2003, just prior the the US taking the rest of Canada as the 51-58th States. The Communist party won a landslide election victory there in 2008. It is effectively part of the European Common Market which is in turn controlled by the Scientologist stronghold of Neo-Deutchland.
In Transhuman Space, a 2031 Referendum has BC and Alberta separating from Canada. They separate in 2033 and form the Union of Alberta and British Columbia (ABC). In 2036, socio-economic stresses from the "loss of the west" led Quebec and the Atlantic Provinces to dissociate themselves from central Canada and negotiate membership in the EU. In 2041 Montreal separates from Quebec as one of the first Free Cities. By the game time in 2100, Canada is Saskatchewan, Manitoba and Ontario. Quebec is a nation in the EU, as is Newfoundland and "The Maritime Union" (a nation formed of the ex-Atlantic provinces). (I don't own Fifth Wave - the book about Earth, so there may be more details in there about Canada and it's ex provinces).
I'm going to head for bed, but will dig through my other games later.