Let's say a creature marks a wizard. Because of the mark, the wizard gets a -2 to attacks that doesn't include the creature that marks it. If the wizard uses some kind of AoE, such as scorching blast, and the marking creature is in the area of effect, does the wizard get a -2 to any of the attack rolls because the marking creature was in the AoE or does the wizard get -2 to all other creatures except the marking creature? The confusion is due to the fact that one effect generates multiple attack rolls.