Yeah, that is rough. I hadn't GMed much, but when I finally agreed to, and half my players built characters that were inappropriate for the (prewritten) adventure, I knew we were in for a bit of trouble. The game system also requires min-maxing for certain basic character ideas, but then the adventures put forward challenges that hit characters in singular pain points, sometimes where they've dumped a stat. Sure you only need one face most of the time, but when everybody has to roll on strength to survive a flood....Not actually. You need varied monster roles that synergize with each other. You need traps and hazards and interesting terrain to make the fights dynamic. Hopefully it's all thematically appropriate. You can't just "add up 4 orcs and you're good."
Avenger (striker) - engaged
Barbarian (striker) - not engaged
Hexblade (striker) - engaged
Wizard (controller) - engaged
Cleric (leader) - not engaged
Ardent (leader) - not engaged
No defender, because no one will play one (despite my begging them for 6 months)
They've managed surprisingly well in spite of that, but not without complaints.
But 4E without a defender? I have to admit I would have bluntly told the group that was going to be frustrating at best. All the more so if most of your players aren't even engaged. (And that would've been another reason I wouldn't do 4E—it can handle maybe one player not being engaged.)
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