OOC: Hmm, intriguing. You could use the "attack from square" rule for things like cover and flanking, but I'd think the solid fog affects the creature as a whole, or not. Even one square in the solid fog may impose the penalties. After, you take the damage, right? So, clearly the fog affects the creature. I guess it comes down to movement. If the creature is still penalized on movement, then he still gets the attack/damage penalty, IMO.