Conceptually, it's kind if the opposite of Heroes. In Heroes, normal people start manifesting superpowers, and a shadowy organization is hunting them down for their own ends. The viewer is definitely led to be on the side of the people manifesting the powers. (Heroes = good guys.)
In Painkiller Jane, normal people start manifesting superpowers, but in the process they all end up "bad." (There was something explained about their inability to tell good from evil or something like that - I can't recall the exact explanation.) A shadowy organization is hunting them down to neutralize the threat that they represent. The viewer is led to be on the side of the shadowy organization. (Neuros = bad guys.)
The problem is, Painkiller Jane herself is basically Claire, the cheerleader character from Heroes, aged several years and given DEA training. It shouldn't be a big surprise that the show pales in comparison to Heroes, which more or less provides everything this show provides and a whole lot more.
I'll give it a couple more episodes - it could turn out to be a pretty decent show. It kind of reminds me a bit of the "hunt the mutant" episodes of The X-Files, which I always liked a lot better than the "mythology" episodes.
Johnathan