JEB
Legend
True, the Great Wheel could wind up being the last vestige of alignment in the game. Though of course, you could also describe the cosmology without continuing to attribute the layout to alignment. Might even make certain planes' placement less odd (like the Beastlands).I don't think it's going away entirely. 5E has committed firmly to the Great Wheel, more's the pity, and alignment is pretty integral to the Wheel.
Plus the Great Wheel isn't the only cosmology we've seen in 5E - there's also Eberron's (though Tasha's actually linked it to Sigil, for what I think was the first time) and the MTG multiverse (as seen in Ravnica and Theros). Maybe they'll go back to 3E's approach, and make cosmologies more ad-hoc.