I'm sorry, I have to disagree with you. I watched Farscape from the beginning, then stopped, then tried to jump back in. Despite having watched the first couple of seasons, I was totally lost. I had no idea what was going on in the new episodes. None. They bore no resemblance to my prior two seasons of the show.
I jumped into Stargate FAR into it (having never had Showtime). I had no trouble picking it up. None. With the exception of a few things here and there, it all made sense to me.
Others have mentioned shows like Buffy & Angel - I agree. I have no prayer of jumping into one of those shows now. And, that is having a huge impact on them. Buffy is losing $1 Million per episode right now, and Angel has ratings below some PAX TV shows. Both are doomed to cancellation. And while I am sure there are plently of good OTHER reasons why those two shows are struggling, at least one good reasons is their overly-serialized nature.
Others mentioned ER, the Practice, and related popular shows - bullcrap. You can jump into those shows at almost any time without trouble. The most you need is a couple of recaps.
24 - It is serialized, but on a season by season basis, with most plot threads (though not a few major ones) generally wrapped up in a few episodes. It is not entire show run basis of serialization. That means they can give you pretty much EVERYTHIHNG you need in the first couple of minutes of the show. Generally, all they need to do is recap 3 plot threads, and you are set. Farscape could not possibly do that.
I think people who refuse to admit Farscape had a problem with too much serialization are not being realistic. If I were alone in my experience, I'd give the argument more attention. But I'm not. Several others here (and I consider this a sophisticated crowd) experienced the same thing, and Sci-Fi channel itself said that is what they werehearing also. It was happening, and to a fairly wide extent, and was hurting the show. It wasn't happening with other shows like Stargate SG-1 (which not only moved times, but moved channels a bunch of times, and got it's start on a channel most people do not have).