If someone wanted to use a mirror to target a medusa with a magic missile I'm not going to say no.
If you have a mirror around a medusa the best tactic is to do a light cantrip and get it to look at it's own reflection.
If the medusa sees itself reflected on a polished surface within 30 feet of it and in an area of bright light, the medusa is, due to its curse, affected by its own gaze.