Deus Ex would have such strong potential, no matter whether you're doing it during the time of Adam Jensen or J.C. Denton. An immersive sim with the right collection of rules (maybe rules light, or at-least something flexible?) combined with great rules on how to make quests and 'dungeons'* with multiple solutions, set up clues and things to come back to - would be a great little science fiction game.
It may need some sensitivity to comb through some conspiracy stuff** particularly for the latter era, but honestly I think I'd adore it.
* enemy bases, corporate lairs, etc. - don't know what to call it outside of fantasy TTRPG space.
** Deus Ex mainly uses conspiracies as backdrop and strongly focuses on the theme of 'corporations and capitalists as extreme dangers to society, particularly when they overtake the government' and on so on and so forth - not necessarily problematic. The problem is, of course, is that many conspiracies back then lead to more awful things down the rabbit hole, such as antisemitism, all sorts of racism, anti-vaxx etc.
And it has gotten much worse since then. The whole FEMA thing in Deus Ex, and, especially, the plague can read VERY POORLY if you don't take into account that the game was written in the later 90s, before 9/11 and before the internet enabled extreme conspiracy theories to rise to the top.
So I think those elements would need to be handled with care.
I think this is partly a big reason why the Adam Jensen games still feature the conspiracies around corporations and capitalists but focus primarily on augmentation; you are much less likely to run headfirst into actual awful beliefs people hold...
