Whichever setting Antiquities is from, and the war between
Mishra and
Urza.
That's Dominaria, which hasn't been central to the game in well over a decade.
I don't think that would work very well. First, with the exception of a single set in 2018 named
Dominaria, the game hasn't been set on that plane since 2006-2007 (Time Spiral block). The last set in that block, Planar Chaos, was the 43rd Magic expansion set. The current set, Strixhaven, is the 87th Magic expansion set.
Second, Dominaria is more heavily damaged than Toril is. Since all the three set blocks Magic ever produced have the exact same narrative: Set 1 - introduce status quo, Set 2 - plane is set up for total annihilation, Set 3 - plane is completely unrecognizable from Set 1's status quo. (It's super lazy writing and it's one reason I'm glad they abandoned block storytelling.) This happened about... eight to ten times to Dominaria before the end of Time Spiral block? Everything from artifacts nuking all magic (Antiquities) to rapid climate change (Ice Age) to multiple extraplanar/fiendish invasions (Slivers
and Phyrexians) to time itself nearly unravelling before remaking the nature of magic in the multiverse (Time Spiral). Each block represents a different time and, aside from the names of place, are basically not recognizable from each other.
Imagine you were creating a setting book for DC comics. Do you go with golden age, silver age, pre-crisis/bronze, post-crisis, infinite crisis, new 52, etc., knowing that your fan base will have different desires? Your choice is to make a 600 page book nobody can afford, or a 200 page book that doesn't satisfy anybody, or three 200 page books that will all sell terribly.