Thanks to all who replied about running D&D in a MtG setting, it seems that there are at least a few of you out there.
Apart from that, for as long as I can remember (and it's a long time now), there have been people who have hated D&D for being too mainstream, and overshadowing other games that were, in their eyes, more perfect and therefore "objectively" better. For me, it does not work that way, a game matches your tastes and expectations, it's good for you, and that is all that there is to it. I've tried tons of other games throughout the decades, some for long campaigns, others for shorter ones, some that played really well for us and others that did not, but always came back to D&D like most of the people in the groups that we play with, sometimes with good results and sometimes with only OK results (2e and 4e were not good for us, for various reasons, when 3e and 5e really worked for us, again for various reasons).
But in terms of settings, none of us are really MtG players, and from the little playing that I've seen, it's always been fairly technical and actually the lore mattered extremely little to the people I played with, so I have absolutely no attachment with the settings, whereas I've had incredible adventures in Mystara, Greyhawk, Planescape, Spelljammer, Dark Sun, etc., adventures that were mostly shared with people in our groups so this is also why we come back to them and they feel comfortable and exciting.