Henry
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1) The "Loner" hero.
Ask every player to come up with one paragraph of decription of their character. Ask they to include two ways in which they have previously known at least two other characters. Tell them that they don't have to provide any background, but inform them that if they do not, one WILL be provided for them.
Then you have free reign to insert as many long-lost uncles, cousins and lovers as you see fit.
2) The really really odd PC.
Give them only the races and classes from the core books. Even then, seven races and eleven classes is a darned wide range to make characters in! If they can't play something original from that mix, then they need to start getting more creative. I've played at least once to thrice a month for the past 4 years NON-STOP, and there are STILL races and classes I want to try!
3) The PCs not knowing each other.
The first suggestion would take care of this.
I hope some of these are useful!
Ask every player to come up with one paragraph of decription of their character. Ask they to include two ways in which they have previously known at least two other characters. Tell them that they don't have to provide any background, but inform them that if they do not, one WILL be provided for them.

2) The really really odd PC.
Give them only the races and classes from the core books. Even then, seven races and eleven classes is a darned wide range to make characters in! If they can't play something original from that mix, then they need to start getting more creative. I've played at least once to thrice a month for the past 4 years NON-STOP, and there are STILL races and classes I want to try!
3) The PCs not knowing each other.
The first suggestion would take care of this.
I hope some of these are useful!