I hope Monte's working on something incredibly new and/or different. Otherwise, who's going to buy it? If you like 4e, you'll stick with it. If you like 3.x, you'll probably stick with Pathfinder. If you don't like either, you're not likely to like anything that resembles either.
The best we can hope for, and it's TOTALLY POSSIBLE, is a much more modular game that "can" have some of the innovations of 4e if you want them, and "can" have some of the crunch of "3x", if you're so inclined, and still be compatible (within reason) with previous editions. One of the greatest things about the OSR is that everything is so compatible with minimal effort. i.e. To make B2 The Keep on the Borderlands work with OSRIC, S&W and/or 2e is so minimal, it's amazing. To make it work with 3x is only a little bit harder, while 4e is such a different beast it's almost not worth the work... which is why Pathfinder is so popular.
Monte Cook "got" D&D, which is why 3x and its derivatives are so useful even to Old-school gamers.