By the by, dharma is distinct from karma, meaning;
Dharma is a sanskrit word and a concept of eastern religions. Simply explained, it is the way of the higher Truths, a lifestyle that leads to minimum accumulation of karma and is therefore the fastest path to personal liberation.
Karma, by comparison is;
The doctrine of karma states that one's state in this life is a result of actions (both physical and mental) in past incarnations, and action in this life can determine one's destiny in future incarnations. Karma is a natural, impersonal law of moral cause and effect and has no connection with the idea of a supreme power that decrees punishment or forgiveness of sins. Karmic law is universally applicable, and only those who have attained liberation from rebirth, called mukti (or moksha) or nirvana, can transcend it.
Thus perhaps we, the audience, are being told that the survivors are on the island because they deserve to be stranded there for past transgressions and until they make some sort of proper recompense or atonement, all attempts to escape will fail.
Certainly a number of the characters have made a number of past transgressions, including Charlie (drug abuse, theft, etc.), Kate (robbery, getting lovers killed through negligence, etc.) and Sawyer (theft, murder, etc.).
However, others have made few such transgressions yet are none the less marooned on the island, such as Jack, Locke and Michael. Whatever transgressions they made are both debatable and minor.