Ok, Science can be one of three things:
1 - Magic (Sufficiently advanced technology is indistinguishable from magic)
2 - Psionics (Opposes magic by relying on ones own mental ability to exert control on reality rather than using magic itself as a tool; Not very science-y but Greek-sounding power names and crystal theme have a very Sci-fi feel)
3 - Something Totally Different (Until proper rules for futuristic weapons and tech are thrown together, this would be about the equivalent of the Craft portfolio; you have better stuff than everyone else)
Choosing 1 renders this the equal of the magic portfolio (a strong portfolio, and usually held by powerful pantheon members). Choosing 2 means that everyone who thinks Psionics are magic with a different rules system are going to dislike the portfolio. (and people who dislike psionics in general as well) Choosing 3 means remaking an entire portfolio; this might be the best option, but requires the most effort.
Also, I would ditch the unique portfolio powers, as cool sounding as they are, and put in regular core spells, and just include the new spells in whatever supplement covers technology more comprehesively as a side bar or something.