Absolutely. Pretty sure my newbie player doesn't really get why any of these exceptions occur, and even my more experienced players hit a wall sometimes. I had a fight with a monster that cast darkness and the cleric - an experienced player! - didn't quite get why guiding bolt had disadvantage when fired at the monster in the darkness while the bard's hideous laughter just couldn't target the monster in the darkness and their shatter had no problems forcing a saving throw. Grappling introduces similar ambiguity (and is distinct from Restrained!).
It'd be really nifty if the modularity of 5e included an easy way to simplify a lot of this for some of the less math-friendly players. I think 2014's Proficiency Die has some legs on making it more distinct, but still...lots of overhead.