I'm currently thinking about a new campaign world, tenatively titled "Athanatos", which I'd loosely describe as "transhumanist fantasy".
Basically, people in this world have a pretty good understanding of souls, and what happens after "death": Basically, the soul separates from the now disfunctional body, and slowly dissipates into astral space.
But in this world, mages have figured out how to attach a free-floating soul to a new body - not just a restored old one. The soul could also inhabit the body of a clone, a unique body with lots of alchemical enhancements, or even that of a golem. And it isn't required that your original body is dead...
Indeed, many people who can afford it maintain several bodies: "This one with the equisite facial features is the body I wear when I attend business occasions, this lean and muscular one I use for weekend parties, this arachnoid construction golem is for my day job in the mining industry, and this specially-bred eagle I use for recreational flying when I want to get away from it all...
Does that sound interesting?
Oh, and
Urbis probably qualifies as "non-standard" fantasy as well - even though it's based partially on Europe, it's not based on
medieval Europe, but on Europe in the Industrial Age...