What I do see is a lot of new campaigns starting, whether by choice or death. Some characters just will not be viable now. You talked about one or two special material weapons, that only works if you have a big two handed weapon, to bypass the damage threshold of the other DR's. Which invalidates archers, twf, small warriors the best they can get is a d8, and without massive change the monk. The haste spell being revised means if you didn't stock up on save or die spells your characters had it at high level and if the pit fiend is any example high end fights are now going to end in a character death. True you can be ressurected but how many times can that happen? So much for making it to epic level. You can't just go back and change spells and feats, and you certainly can't change your race.