GlassJaw
Hero
In truth, a point here or there will rarely matter much. How often will a BBEG go down by 1-2 points. Not 3, not 4, but 1-2 points at such a point that him NOT going down will result in death or disability for a party member.
I think the same holds true when we say something is MAD and we are aghast that someone has a 16! in an ability instead of an 18 or 20 when they "should." Even with bounded accuracy, we often make much more of this stuff than is warranted.
I will take a d12 weapon at times because I like the d12 and the thrill of maybe rolling a 12. Its fun. Its chance and adventure.
There are some abilities which impact only one die of weapon damage and in these fringe racial/feat cases, I suppose a d12 is more attractive.
I am not suggesting a d4 is as good as a d12, but 2d6 vs. d12? (shrug)
Is there a big difference? No, I guess not. But where do you draw the line? By your philosophy, rules, numbers, mechanics, etc. should be hand-waved. "Meh, close enough, not that big of a deal."
As someone who's worked as a professional designer, it matters, even if the analysis only serves as a starting point or as a way to understand more about the system.