The question posed is addressing a singular person ("you"), but every answer available suggests a response is made by a group ("we"). That changes the perspective from individual preference to group consensus. Should the question have been "How likely is your group..."?
Personally, I don't have a group to consult with, and it is highly unlikely I'll ever run or play again. But if the opportunity presented, I'd have to consider my role in a potential game, as well as expectations of the game itself. One shots, for example, could be anything. Longer campaigns, I'd want a system that I would at least be interested in using or learning for some time.
As a player, I would happily play whatever system is offered. System mastery was never my concern, and I enjoy roleplaying interesting, quirky, and entertaining characters more than rolling dice for everything. I'm playing a character first. Filling a role for party composition is secondary.
As a GM, I would be most comfortable with a system I am familiar with and enjoy using. System mastery matters more behind the screen, thus I would not want to squander a rare opportunity to run for others unless it was a system new to everyone. That said, I could run a 5e D&D with little effort, but it has never been very exciting to me. I've zero interest in using the new version of the rules, which I will not spend money for. My choice would be a 4e D&D, or FFG Star Wars, which are my favorites systems to use. I had dipped my toes into Starfinder shortly before the 2e was announced. I think it still has potential, with the right adventure and the right group.
I would absolutely love to try something like Sword World after reading about it recently. It's such a cool, casual, and different kind of fantasy RPG experience, one that can be enjoyed and satisfied in single sessions without a lot of prep, build, or planning.
I've always wanted to get into Shadowrun, but the rules system and world building always felt clunky and disjointed. Shadowrun Anarchy had an interesting approach, but unfortunately never got more traction.
I'm happy with board games that feature campaign with co-OP or solo modes, but that's going off the rails now. I guess this is just to say that I still have more games left in me than I have gaming.