The new Player's Handbook contains 12 character classes, each with 4 subclasses, making 48 in total.
- Barbarian: Path of the... Berserker, Wild Heart, World Tree, Zealot.
- Bard: College of... Dance, Gamour, Lore, Valor.
- Cleric: Life, Light, Trickery, War domains.
- Druid: Circle of the... Land, Moon, Sea, Stars.
- Fighter: Battle Master, Champion, Eldritch Knight, Psi Warrior.
- Monk: Warrior of... Mercy, Shadow, The Elements, The Open Hand.
- Paladin: Oath of... Devotion, Glory, The Ancients, Vengeance.
- Ranger: Beast Master, Fey Wanderer, Gloom Stalker, Hunter.
- Rogue: Arcane Trickster, Assassin, Soulknife, Thief.
- Sorcerer: Aberrant Sorcery, Clockwork Sorcery, Draconic Sorcery, Wild Magic.
- Warlock: Archfey Patron, Celestial Patron, Fiend Patron, Great Old One Patron.
- Wizard: Abjurer, Diviner, Evoker, Illusionist.