I played through it (twice through a small part of it, as it was ripped out and inserted into another campaign) and then read through the book afterwards.Was this an experience gained through only playing? Was this an experience gained through being DM?
In play of the adventure path we completed about half of the "optional side missions". When we finished the campaign we continued a second campaign from the endpoint of ToA by focusing on pirate hunting in the ocean around Chult, building up a ruined keep in the Port, and our party becoming a regional power group....presumably with the GM using the ToA adventure path to fill in the details on places we visited outside of the ToA campaign.
Of my 10 examples....name one that cannot be run as it is presented in the book without there being a Death Curse mechanic in play.